01/12/202501/12/2025 by Aleix Nin

RAYPA AUTOFILL External Water-Supply and Management System

In many laboratories, advanced sterilization and culture media preparation depend on something as basic as it is essential: having a stable water supply, a functional drain, and a responsible approach to water consumption. Modern autoclaves and media preparators require large volumes of water for cooling and drainage systems, which can result in intensive—and sometimes inefficient—use of this resource. Additionally, some facilities operate with inconsistent water supply, insufficient flow, or no drainage at all, making it challenging to keep processes running smoothly without increasing water waste.

For these environments—and for any laboratory that wants to ensure operational continuity while measurably reducing water consumption—RAYPA has developed AUTOFILL, a closed-loop external water-supply and management system for sterilization, cooling, and drainage processes.

What AUTOFILL is and how it works

AUTOFILL is an accessory that functions as an external water-supply and management system, built around a storage tank and integrated pumps. It guarantees continuous operation even when the laboratory lacks a stable water network, has insufficient flow, or has no operational drain.

The system operates as a closed loop: it supplies water to the equipment and recirculates the water used during sterilization, cooling, and drainage, ensuring a stable flow while significantly reducing both consumption and waste.

It also includes audible alarms that notify users of low water levels or a full tank—preventing unexpected interruptions during a cycle.

AUTOFILL-TLV-200: application for Top Line autoclaves

The AUTOFILL-TLV-200 version is designed specifically for Top Line autoclaves – TLV Series. Its role is clear: to keep the autoclave running even when the facility does not provide optimal water utilities.

In installations without a constant water network, with insufficient flow, or without drainage, AUTOFILL-TLV provides autonomy through its tank and pressure pump, managing the water involved in sterilization, cooling, and drainage processes.

Download the technical datasheet for AUTOFILL-TLV-200

AUTOFILL-MP-200: application for AE-MP and TLV-MP media preparators

The AUTOFILL-MP-200 version is the equivalent solution for Classic Line (AE-MP) and Top Line (TLV-MP) media preparators.

These units include a sterilization phase followed by a rapid-cooling phase, the latter performed through a water-cooling coil. For this reason, having a reliable water supply and proper drainage management is essential for productivity and reproducibility. AUTOFILL-MP guarantees that continuity even when the laboratory lacks a stable hydraulic infrastructure.

Download the technical datasheet for AUTOFILL-MP-200

Technical advantages of AUTOFILL

1. Continuous operation: Designed to ensure uninterrupted operation in environments with water-supply or drainage limitations.

2. Closed-loop system: Recirculates the water used during sterilization, cooling, and drainage, eliminating dependence on a permanent external supply.

3. Safety and alarms: Equipped with audible alarms to signal low water level or a full tank, minimizing potential interruptions.

4. Efficient water management: Optimizes water use by supplying only what is needed and enabling its recovery.

5. Ready to install: AUTOFILL is supplied as a complete set that includes:

Transport cart with wheels and braking system
200 L tank with minimum and maximum level sensors
Pressure pump with adjustable switch
Heat exchanger
Connection hoses and 1.5 m power cord

ECO benefits: tangible sustainability in daily operations

AUTOFILL stands out as an ECO-focused system designed to maximize water efficiency in sterilization and media-preparation workflows. Its closed-loop operation optimizes water consumption, enables reuse, and significantly reduces waste—supporting a more sustainable and controlled laboratory operation.

These advantages are especially relevant in laboratories with limited supply, insufficient flow, or discharge restrictions. In such environments, AUTOFILL transforms infrastructure limitations into a real operational improvement, ensuring more responsible, efficient, and consistent water use without compromising sterilization performance, cooling efficiency, or process reproducibility.

Recommended use cases

1. Absence of drainage: Allows collection of cooling water without requiring an external drain.

2. Lack of a cooling-water supply: Provides water for cooling; water is later discharged through the drain, without reuse.

3. Lack of both cooling-water supply and drainage: Operates as a closed-loop water system with integrated cooling, eliminating the need for continuous water consumption and discharge. This is the most efficient and sustainable option.

Enhance your autoclave or media preparator with the AUTOFILL system

AUTOFILL-TLV-200 and AUTOFILL-MP-200 are designed for labs that don’t want infrastructure limitations to restrict their sterilization or media preparation capacity. They provide operational continuity, efficient water management, and a realistic ECO approach—especially valuable in settings with constrained water resources.

If you want to confirm compatibility with your model or determine which configuration best fits your installation, reach out to our technical team.

Request more information

20/11/202517/10/2025 by Aleix Nin

Validation and Qualification of RAYPA Autoclaves

Validating an autoclave is not simply about checking whether it reaches the correct temperature.

In regulated environments—such as the pharmaceutical and biotechnology industries—validation means demonstrating, through documented evidence, that the equipment performs according to its design, meets the applicable sterilization standards, and that data management processes comply with the corresponding regulations.

Two Areas of Qualification

For our Top Line autoclaves, validation can be approached from two complementary angles:

1. Functional Performance of the Autoclave
Ensures that installation, operation, and performance comply with the manufacturer’s specifications and applicable standards. It includes all necessary thermal and safety tests required to prove that the sterilization process is reproducible, safe, and compliant.

2. Electronic Records Management
Ensures that the acquisition, storage, and traceability of data and electronic signatures comply with FDA 21 CFR Part 11 and GMP Annex 11, both in the equipment’s microprocessor and, when applicable, in the external management platform (RAYPAcloud).

Qualification Options: By RAYPA or Through Third Parties

We understand that every laboratory has its own compliance strategy. For this reason, RAYPA offers two flexible approaches:

Full Qualification
Performed by RAYPA technicians or authorized entities. It includes commissioning, complete qualification of the autoclave and its software, and the generation of all required documentation to meet the most demanding regulatory standards.
Qualification Through Third Parties
We provide detailed protocols and documentation so that your internal team or a trusted qualification agency can execute the qualification independently. This option maximizes flexibility and alignment with your internal processes.

Both approaches are designed to ensure efficiency, safety, and regulatory compliance, adapting to the degree of outsourcing you prefer.

Download the Qualification Services Datasheet

Qualification Phases: IQ, OQ and PQ

Autoclave validation is normally structured into three phases:

IQ – Installation Qualification: Verifies that the equipment has been installed according to the manufacturer’s specifications and configuration requirements.
OQ – Operational Qualification: Confirms that the system operates consistently within the defined parameters, including alarms, interlocks, and critical controls (temperature, pressure, time, F0 when applicable).
PQ – Performance Qualification: Demonstrates that the process meets specifications under real-world operating conditions and with a representative load.

After completing IQ and OQ, an IOQ Report (IOQR) is issued, consolidating all results and evidence of compliance. This provides full project traceability and paves the way for PQ and routine operation under a validated state.

Software Qualification and Data Integrity (FDA 21 CFR Part 11)

In regulated environments, what is not recorded does not exist. Therefore, in addition to qualifying the equipment itself, it is essential to validate the controller software and, when applicable, the external management platform (RAYPAcloud).

This qualification applies specifically to computerized systems and aims to demonstrate compliance with FDA 21 CFR Part 11 and GMP Annex 11.

We offer two software-qualification packages (controller and/or platform), delivered with complete documentation required for FDA/GMP audits:

VP (Validation Plan): scope, methodology, resources, and schedule.
URS (User Requirements Specification): user and system requirements.
RA (Risk Assessment): system or process risk analysis.
Software IQ and OQ: verification of proper installation and operation according to specifications.
IOQR: final report with results and objective evidence.

This approach ensures full traceability, data integrity, and regulatory compliance throughout the entire system lifecycle.

Why Choose RAYPA

360º approach: from equipment IQ-OQ-PQ qualification to software validation and FDA/GMP-compliant data management. A single point of contact—less friction, faster execution.
Compliance-ready technology: Top Line autoclaves are designed with the connectivity and data-control capabilities needed for paperless operation, reducing data-integrity risks and accelerating inspections.
True flexibility: choose between full RAYPA-managed qualification or third-party documentation packages, and select the software-qualification model that best aligns with your IT policies and workflow.

When Validation Is Essential

When manufacturing or testing pharmaceutical, biotechnology or medical products.
When your processes require data integrity and traceability with electronic records and digital signatures.
When you need solid documented evidence for audits or for technology transfer to new facilities or production lines.

In all these cases, RAYPA helps translate regulatory requirements into executable protocols and clear evidence.

Take the Next Step

Do you want to qualify your Top Line autoclave or need to align your electronic records with FDA 21 CFR Part 11?
Our technical team can guide you toward the most efficient qualification pathway and help you define the digital quality-management approach that best integrates into your environment.

Request more information

15/09/202515/09/2025 by Aleix Nin

In laboratories and research centers with a high workload, every minute counts. Reducing cycle times, planning for technological upgrades, and ensuring continuous operation are key factors to increasing productivity without compromising quality or safety.

In this article, we introduce three accessories specifically designed to make your Top Line autoclave work faster, more efficiently, and without unnecessary interruptions.

1. Internal Radial Fan

Cooling up to 80% faster

Compatible with autoclaves from the TLV-FA and TLV-DUAL Series with rapid cooling systems, this accessory is factory-installed and works alongside the water coil to drastically reduce cooling times:

Up to 80% in the TLV-FA Series.
Up to 60% in the TLV-DUAL Series.

With a speed of 1300 rpm and a compact design (Ø200 mm x 173 mm), the fan enables more cycles per day, boosting the overall performance of the equipment. It is ideal for laboratories that sterilize large volumes of liquids, where cooling speed is critical.

Note: Its installation reduces the usable chamber height by 70 mm, a factor to consider depending on the type of load.

Download technical datasheet

2. Adaptation Kit for the TLV-DUAL Series

Modular evolution of your autoclave

This kit allows any Top Line autoclave from the TLV-S, TLV-PD, or TLV-FA Series to be prepared for a future upgrade to the TLV-DUAL Series.

Key benefits:

Modular evolution: start with a simpler unit and upgrade when needed.
Cost optimization: reduce initial investment and avoid replacing the unit.
Operational flexibility: adapt the technology as your needs change.
Sustainability: extend the service life and minimize waste.

The adaptation must be requested at the time of purchase and leaves the unit ready to integrate super-drying and/or rapid cooling systems in the future, while maintaining quality and certification standards.

Download technical datasheet

3. Water Supply and Management System

ECO solution for efficient consumption and water reuse

A closed-loop water supply system designed for environments without constant access to a water network, with insufficient flow, or without drainage.

Key functions:

Reuses water employed in sterilization, cooling, and drainage processes.
Maintains a stable flow thanks to integrated tanks and pumps.
Reduces consumption and water waste, improving costs and sustainability.

Ideal for facilities with infrastructure limitations or for those seeking an eco-efficient solution.

With these three accessories, you can shorten cycle times, plan upgrades without replacing your unit, and ensure uninterrupted operation—even in environments with infrastructure limitations.

Request more information

19/08/202518/08/2025 by Aleix Nin

Modalidades de gestión de calidad digital

In regulated environments, digital quality management is not optional—it is a strategic necessity. Traceability, regulatory compliance, and immediate access to information are essential to ensure safe, auditable, and efficient processes.

At RAYPA, we develop advanced digital quality management solutions tailored to the specific requirements of each laboratory. We offer 6 options to manage the quality of data stored both in the autoclave’s microprocessor and in the RAYPAcloud management platform, with different levels of connectivity, privacy, and FDA compliance.

Our Top Line autoclaves and media preparators are our flagship products and the preferred choice of pharmaceutical companies, biotechnology firms, and research centers in more than 100 countries. Designed with cutting-edge technology, they enable compliance with GMP and FDA regulations, operation in fully private environments, or seamless integration with LIMS and Active Directory systems.

Below, you will find all the available options, their features, and benefits—so you can choose the one that best fits your laboratory.

Most Popular Options

Private Standard

Maximum security and FDA compliance

Data is stored both in the autoclave controller and on a private server, with access to the offline management platform via a local area network. Both the controller and the platform are fully FDA 21 CFR Part 11 compliant. Includes automatic backups, complete audit trails, synchronous remote diagnostics via TeamViewer®, and manual updates.

✅ Ideal for industries that require maximum security, complete control, and certified traceability.

Cloud Standard

Full connectivity from anywhere

Stores data in both the controller and the cloud (AWS USA or EU), allowing online access to the platform from any device. Provides centralized management of multiple units, remote administration of users and programs, alert notifications, asynchronous remote diagnostics, and over-the-air updates.

✅ Perfect for those seeking flexibility, remote management, and high availability without the need for FDA compliance.

Other Options

Cloud-comply

Partial FDA compliance with advanced connectivity

Data is stored in both the autoclave controller and the cloud (AWS USA or EU), allowing online access to the management platform from any internet-connected device. Controller management complies with FDA 21 CFR Part 11, but cloud storage is not Part 11 compliant.

✅ Designed for users who require regulatory compliance on the equipment itself while also benefiting from advanced monitoring and remote administration features.

Essential-comply

FDA compliance without connectivity

All data is stored exclusively in the autoclave controller, configured to enable features such as audit trails, backups, and other tools that ensure compliance with FDA 21 CFR Part 11. It does not support remote access or cloud connection.

✅ Recommended for laboratories that do not require remote access but need to guarantee the integrity, traceability, and legal validity of their records.

Private Basic

Total privacy without connectivity

Data is stored on a private server, with access to the offline management platform through the local area network. While it is not FDA 21 CFR Part 11 compliant, it offers maximum internal security for those who prefer to keep all data within their own infrastructure without relying on cloud services.

✅ Ideal for environments with strict internal privacy policies.

Essential

Basic solution without connectivity

Stores data exclusively in the autoclave controller, with no cloud access or advanced digital management functions. It is not FDA 21 CFR Part 11 compliant.

✅ The simplest and most economical option for users who require direct, straightforward management.

Comparative Overview of the Options

We have prepared a summary document with the specifications of each option so you can easily compare levels of connectivity, privacy, and regulatory compliance, and choose the one most suitable for your laboratory.

See Comparative Overview

Expert Support and Comprehensive Assistance

At RAYPA, we don’t just provide technology—we also ensure its successful implementation:

Personalized consulting
Custom developments and tailored integrations
Equipment and software qualification
Training on use and maintenance
Advanced technical support and maintenance

Take the Next Step Towards Full Digital Traceability

Optimize your laboratory’s quality management, reduce audit times, and enhance the security of your processes.

Request an expert consultation or a demo today and discover which option is best suited for your laboratory.

Request Expert Consultation

22/07/202522/07/2025 by Aleix Nin

Can you imagine resolving any technical issue with your RAYPA equipment without travel and with real-time expert assistance?

At RAYPA, we understand that our customers need robust, reliable, and safe equipment. However, we also recognize that quick, accessible, and effective technical support is essential for ensuring uninterrupted processes.

Agile Support Anytime, Anywhere

At RAYPA, we know that when a technical issue arises, response time is critical. One of the greatest strengths of our remote technical service is agility: we offer immediate assistance, regardless of your location.

Thanks to remote assistance, our specialists can diagnose and resolve most issues in real-time, eliminating unnecessary travel and significantly reducing waiting times.

With our remote service, any user can access specialized technical support instantly, offering the same effectiveness and personalized attention as an in-person visit but with the convenience and efficiency of a digital environment.

This service ensures that all our users, regardless of their geographical location, can receive specialized technical assistance conveniently and efficiently.

Increased Convenience and Operational Ease

Our equipment is ergonomically designed to be intuitive and user-friendly. Nevertheless, operational doubts or minor technical issues can occasionally arise and require rapid clarification. Our remote technical service provides an added layer of operational convenience, allowing these situations to be quickly resolved through guided, personalized assistance without delays or travel.

Through this support method, users can perform checks, basic adjustments, or even resolve minor issues themselves under the supervision of our technical specialists, creating an agile, comfortable, and highly satisfying experience.

Cost Savings and Reduced Associated Expenses

RAYPA’s remote technical service not only boosts operational efficiency but also generates substantial economic savings.

By eliminating physical travel, costs associated with transportation, accommodation, and meal allowances for technical personnel are eliminated. Additionally, resolving issues swiftly minimizes disruptions in work processes, reducing potential losses caused by downtime.

In essence, it’s an effective technical solution that optimizes resources and reduces costs without compromising the quality of support.

Highly Specialized Technical Support Team

One of the cornerstones of our remote technical service is the high level of expertise within our team. At RAYPA, all our technicians receive specialized training focused exclusively on our products, ensuring accurate, swift, and decisive support.

Thanks to remote support, our customers have direct access to these highly skilled professionals, capable of quickly and effectively identifying and resolving any technical issue.

Having a specialized and always-available technical team offers peace of mind, making it one of the most appreciated aspects among our customers.

Enhanced Security and Protection for Users and Equipment

Safety at RAYPA is more than just a feature; it’s an absolute priority. Therefore, our remote technical service plays a crucial role in protecting both users and equipment.

Through real-time monitoring and assistance, it is possible to immediately detect any technical deviations that, if left unattended, could result in severe malfunctions or potentially dangerous situations. This proactive approach significantly reduces operational risks, prevents accidents, and minimizes potential damage to equipment.

Additionally, with direct supervision from our specialists, users can confidently and safely carry out adjustments or basic checks.

In summary, remote support doesn’t just solve problems; it anticipates, protects, and ensures a safe, controlled working environment at all times.

Ongoing Technical Training and Knowledge Transfer

RAYPA’s remote technical service goes beyond simply resolving issues: it educates, empowers, and enhances user capabilities.

Every interaction represents an opportunity to share critical knowledge on equipment operation and maintenance. Our technicians guide users step-by-step, offering clear, practical explanations in real-time, tailored to their specific needs.

This continuous technical guidance translates into:

More efficient and safer equipment use.
Greater operational autonomy for personnel.
Reduction of errors due to misuse or lack of knowledge.

In short, remote support becomes an active learning tool that boosts user confidence, enhances their experience, and ensures the full utilization of each piece of RAYPA equipment.

Key Reasons to Choose RAYPA’s Remote Technical Service

Choosing RAYPA’s remote technical service means opting for a modern, efficient, and user-focused solution. Here are the key reasons why more and more customers trust this support model:

Immediate attention, wherever you are, without the need for travel.
Guided technical issue resolution with real-time expert assistance.
Significant cost savings and reduced downtime.
Highly qualified support delivered by technicians specialized in our products.
Increased safety through early detection of technical issues.
Ongoing training that improves user autonomy and extends equipment lifespan.

Our service transcends mere technical support: it represents trust, efficiency, and protection at just one click away.

Need remote technical support? Contact our technical service team.

Request technical support

01/07/202527/06/2025 by Aleix Nin

With over 50 years of experience manufacturing autoclaves, RAYPA introduces the innovative TLV-DUAL Series, designed to provide advanced sterilization of both liquid and solid loads.

This cutting-edge series stands out for its superdrying and fast cooling systems, optimizing process times and significantly enhancing operational efficiency.

Advanced Technology for Optimal Sterilization

The TLV-DUAL Series offers solutions specifically tailored to meet the most demanding sterilization requirements, combining state-of-the-art technology with functional, ergonomic design.

These autoclaves are available in four capacities – 58, 83, 124, and 169 liters – allowing easy adaptation to different laboratory spaces and load volumes.

A distinctive feature of this series is its dual system, which includes:

Superdrying, utilizing a vacuum pump and heating jacket to ensure complete removal of residual moisture, thus preserving the integrity of sterilized materials.
Fast cooling, achieved via an integrated water cooling coil, substantially reducing cycle times and increasing laboratory productivity. An optional internal radial fan can further shorten the cooling phase.

Superdrying and Fast Cooling System of RAYPA’s TLV-DUAL Autoclaves — Superdrying and Fast Cooling Systems for Advanced Sterilization of Solid and Liquid Loads

Safety and Ease of Use

Safety remains a top priority for RAYPA. TLV-DUAL autoclaves are equipped with multiple safety features, including:

Bacteriological filters that ensure air entering and exiting the chamber remains sterile.
Push-button, mechanically-assisted automatic door, minimizing physical effort and enhancing operator safety.
A modern 7” capacitive touchscreen with digital controls, providing intuitive, precise management of all processes.

Modern 7” capacitive touchscreen from RAYPA's TLV-DUAL autoclaves — 7” capacitive touchscreen

Exceptional Build Quality and Sustainability

Constructed from high-quality stainless steel (AISI-304 externally and AISI-316L internally), TLV-DUAL autoclaves exhibit exceptional corrosion resistance and longevity with minimal maintenance required.

Their fully electric design eliminates reliance on fossil fuels, optimizing water and energy consumption, thus aligning with sustainable practices.

Comprehensive Traceability and Advanced Digital Management

Effective process management and traceability are critical in today’s highly regulated environments. The TLV-DUAL Series offers:

Batch process control to ensure consistent, documented results.
The RAYPAtrace system, including label printers and barcode scanners for complete traceability.
Optional integration with RAYPAcloud digital platform, meeting FDA and GMP standards for secure, centralized management of sterilization cycles from any location.

Flexibility and Adaptability

Designed for swift, straightforward installation, the TLV-DUAL Series integrates essential functionalities into a compact, user-friendly unit:

Simplified water and electrical connections.
Antistatic casters with integrated brakes for easy mobility.
Optional basket lift system, either integrated (FIX-LIFT) or mobile (MOB-LIFT), ensuring safe handling of heavy loads.

TLV-DUAL Autoclave with Basket Lift System — RAYPA’s MOB-LIFT Basket Lift System

Comprehensive Technical Support and Consulting

When you choose a RAYPA autoclave, you benefit from specialized technical support at every stage – from installation and commissioning to predictive and corrective maintenance. Our global network of authorized technicians guarantees prompt, effective service whenever needed.

Ready for More Information or a Customized Quote?

If you’re interested in learning more about the TLV-DUAL Series or need a personalized quote, please contact our sales team.

We’re here to assist you in finding the ideal autoclave for your laboratory.

Request more information

06/06/202506/06/2025 by Aleix Nin

At RAYPA, we believe that no one can better explain the benefits of incorporating the ENODEST distiller into their oenological analysis laboratory than our customers themselves.

For this reason, we interviewed Ana Isabel Patón del Campo, a laboratory technician at the Viticulture and Enology Station (EVE) in Alcázar de San Juan. She is a professional with extensive experience in research and quality control within the Spanish wine sector.

The Viticulture and Enology Station (EVE) of Alcázar de San Juan is a public laboratory specialized in oenological analysis, part of the Regional Institute for Agro-Food and Forestry Research and Development (IRIAF) in Castilla-La Mancha, Spain. Located in Alcázar de San Juan, it features modern facilities and a highly qualified technical team.

EVE provides advanced services to wineries, cooperatives, and regulatory bodies, continuously adapting to sector needs. Moreover, it actively participates in research and innovation projects, collaborating with universities and wine-related entities to foster the development of the wine industry in Castilla-La Mancha.

Ana Isabel Patón del Campo, a laboratory technician at EVE, specializes in oenological analysis and wine quality control. Her professional career has been entirely dedicated to supporting the regional wine industry.

Ana Isabel actively participates in research, technical projects, and conferences related to viticulture, working closely with wineries, denominations of origin, universities, and technological centers. Her contributions significantly drive innovation, positioning EVE as a reference laboratory for certification and wine quality in Castilla-La Mancha.

To begin with, could you briefly explain the main mission of the Viticulture and Enology Station (EVE)?

The Viticulture and Enology Station (EVE) in Alcázar de San Juan is a public oenological laboratory under the Regional Institute for Agro-Food and Forestry Research and Development (IRIAF), which is affiliated with the Ministry of Agriculture, Livestock, and Rural Development of the Castilla-La Mancha Regional Government (JCCM).

Our primary mission is to ensure the quality and safety of regional wines through rigorous analytical control and certification throughout all production stages, with particular emphasis on export.

We operate a modern and efficient laboratory where we conduct routine and specialized analyses for wineries and producers. Our philosophy is to adapt to industry requirements, developing new methods as necessary to deliver timely solutions.

What type of analyses do you typically perform with ENODEST distillers?

We typically use ENODEST distillers to distill wines and other wine derivatives accurately, determining their alcoholic strength by volume. This analysis is essential for ensuring regulatory compliance, especially for certification and quality control processes required in both domestic and international markets.

What factors influenced your decision to choose RAYPA’s equipment again over other options on the market?

We decided to trust RAYPA distillers primarily due to our previous positive experience with other equipment from this brand. Daily, we need robust, reliable equipment that provides consistent results without complications.

How long have you been using ENODEST equipment in your lab, and how many units do you currently have?

Our laboratory has a long history of serving the wine industry since 1927. Throughout all these years, ENODEST equipment has been our technicians’ preferred choice due to its effectiveness. We have acquired multiple units at different stages, and they have become integral to our daily operations.

Which specific features of the ENODEST distillers are most useful in your daily activities?

The feature we most value in our daily routine is the programmable timer, allowing us to optimize our workflow and ensure timely, precise results for each analysis. Additionally, the ability to visually monitor the process is another significant operational advantage.

How has the lab staff’s experience been regarding the use and programming of oenological distillers?

Our experience has been very positive. These units are intuitive from day one: the interface is clear, and their operation is straightforward. This significantly simplifies daily tasks, allowing us to focus on obtaining reliable results effortlessly.

Regarding technical support and maintenance, how has raypa’s response been?

We have rarely needed technical support. However, on the few occasions it has been necessary, RAYPA’s response has been swift and effective.

Would you recommend RAYPA’s ENODEST equipment to other laboratories or companies in the industry? Why?

Yes, they are user-friendly, high-quality equipment. For a laboratory like ours, which handles high sample volumes and requires consistent results, ENODEST distillers have proven to be a reliable tool.

Thank you very much for sharing your experience with us!

Download this case study in PDF format

Oenologic Distiller ENODEST

The ENODEST oenological distiller is the perfect equipment for oenological analysis laboratories, wine and champagne cellars, liquor factories, breweries, and ethanol production plants.

It enables precise determination of alcoholic strength by volume in wines, musts, beers, liquors, and high-alcohol beverages, in compliance with OIV, EEC 2676/90, and EC 2870/2000 regulations. Additionally, it assesses volatile acidity and sorbic acid levels.

With a successful track record spanning over 30 years in research and development, this latest generation oenological distiller is built to withstand the test of time. Constructed from premium quality materials, its stainless steel exterior guarantees prolonged durability.

Request a quote

17/07/202506/05/2025 by Aleix Nin

Cómo limpiar instrumentos antes de esterilizar en autoclave

If you’ve ever found residue after what should have been a “proper” autoclave cycle, you already know that pre-cleaning isn’t just a prep step – it’s the foundation of the entire process.

In this article, we get straight to the point: what to do, how to do it, and why it matters.

Why Is Pre-Cleaning So Essential?

Autoclaves use saturated steam under high pressure, but that steam can’t penetrate dried debris, grease, blood, or poorly rinsed detergents.

Think of it like trying to disinfect through a layer of mud – it simply doesn’t work. If the instruments aren’t clean, they won’t be sterile.

The goal of pre-cleaning is to remove:

Organic matter (blood, tissues, bodily fluids)
Inorganic residues (salts, oxides)
Chemical residues (detergents, lubricants)
Biofilms and invisible contaminants

The objective is simple: clean, smooth surfaces free of anything that could interfere with the autoclave’s sterilization cycle.

Key Stages for Effective Cleaning

1. Clean Right After Use

Don’t let contaminants dry. Ideally, remove the bulk of debris at the point of use with a clean, damp cloth. If there’s going to be a delay before cleaning, apply an enzymatic gel or foam to keep organic material moist. This saves both time and wear on your equipment.

⚠️ Important: Never soak instruments in saline. Sodium chloride accelerates corrosion, especially on stainless steel.

2. Safe Transport

Use a sealed, clearly labeled tray to avoid spills, injuries, or cross-contamination. And yes, personal protective equipment (PPE) is non-negotiable: thick gloves, protective eyewear, and a fluid-resistant lab coat.

3. Manual or Mechanical Cleaning

Manual (when necessary or for delicate items)

Use soft-bristled brushes (never metal).
Apply enzymatic detergent and scrub all surfaces, especially hinges and crevices.
Disassemble items if their design allows.
Rinse with distilled or demineralized water. Avoid tap water whenever possible.

Mechanical (washer-disinfector or ultrasonic cleaner)

Load without overcrowding to ensure all surfaces are reached.
Follow the manufacturer’s recommended cycles.
Regularly check filters, spray nozzles, and water temperature.

4. Inspection: Look Closely

Before you even think about sterilization, inspect the instruments thoroughly. Use bright white light or magnification if needed. Check hidden areas, threads, and lumens. If you spot any residue, clean again. There are no shortcuts here.

5. Complete Drying

Instruments must be completely dry before going into the autoclave. Why? Residual moisture can create air pockets or film that blocks steam penetration. Trapped water also promotes corrosion, especially in joints and hinges.

Avoid wiping with cloths that leave lint. Use filtered compressed air or drying cabinets. And if you’re applying surgical lubricant, make sure everything is bone dry – moisture can dilute the lubricant or carry it where it doesn’t belong.

Common Mistakes We See Often

Leaving instruments dirty for hours
Using inappropriate products (bleach, saline, or unneutralized disinfectants)
Not disassembling complex instruments
Skipping the rinse or using tap water
Assuming “looks clean” means “is clean”

Risks of Inadequate Cleaning

Poor cleaning doesn’t just block sterilization. It also promotes premature corrosion, leaves permanent stains and puts users at risk. Can invalidate entire production batches in pharmaceutical settings.

Cleaning Tips by Material Type

Stainless steel: Always dry thoroughly. Avoid prolonged exposure to salts or chlorides.

Laboratory glassware: Use soft brushes only. Rinse well with demineralized water to prevent spots or chemical interference.

Plastics: Ensure they’re autoclavable. Use compatible detergents, as some plastics can warp or degrade.

Silicone or rubber stoppers: Wash with mild detergent, rinse well with demineralized water, and dry thoroughly. Avoid harsh products and confirm autoclave compatibility.

Other materials: Always check the manufacturer’s guidance for cleaning procedures and sterilization compatibility.

Smart Practices That Make a Difference

Train your staff well – cleaning is a skilled task, not a side job
Establish clear, visible, and up-to-date protocols
Conduct spot checks: inspections, residue tests
Keep records of what was cleaned, how, and when

If you’re serious about sterilization, start with serious cleaning. The autoclave does its job, but it’s not magic.

Clean surfaces are the minimum requirement for effective steam sterilization. Doing it right doesn’t take much more time – but it saves you from big problems later.

Still have questions about how to clean instruments before autoclaving with your RAYPA autoclave? Contact us. We’re happy to help.

Sources

“Prevención del deterioro del instrumental” – Blog El Autoclave – Juan José Criado Álvarez, PhD (España). Source: El Autoclave – Prevención del deterioro del instrumental

Guideline for Disinfection and Sterilization in Healthcare Facilities – CDC (EE.UU.) – Centers for Disease Control and Prevention. Source: CDC – Sterilizing Practices

Recomendaciones para la desinfección y esterilización de los materiales sanitarios – AEMPS (España) – Agencia Española de Medicamentos y Productos Sanitarios (Plan Nacional de Resistencia a Antibióticos). Source: Technical document – PRAN/AEMPS, 2017

“A Day in the Life of a Surgical Instrument: The Cycle of Sterilization” (2024) – Robert E. George et al., Universidad de Wisconsin. Source: PMC – Surgical Instrument Sterilization Lifecycle

14/04/202510/04/2025 by Aleix Nin

In sterilization processes, simply reaching the correct temperature inside the autoclave chamber is not enough. What truly matters is whether that temperature is also achieved within the load itself – especially when sterilizing liquids.

Direct monitoring inside the product ensures that all material has been properly sterilized, minimizing microbiological risks. Additionally, this measurement is key to calculating the F₀ value and optimizing cycles by reducing time without compromising the effectiveness of the process.

For this reason, PT-100 flexible probes have become an essential accessory in laboratories and facilities that demand precision, traceability, and validation in their sterilization processes.

What Are PT-100 Probes and How Do They Work?

PT-100 probes are temperature sensors based on the electrical resistance of platinum. The name indicates a resistance of 100 ohms at 0 °C. As the temperature changes, so does the resistance, enabling accurate readings even in demanding environments.

These probes are inserted directly into the load – for example, into a flask containing culture media – so they provide the actual temperature of the product, not just the surrounding environment. This distinction is particularly relevant in liquid loads, where heat penetrates more slowly.

Additionally, the use of PT-100 probes allows cycle control through the F₀ parameter (in compatible models), which represents the accumulated lethality of the process based on the time the sample remains at a specific temperature, using 121.1 °C as a reference.

Why Is It Crucial to Measure Inside the Product?

The temperature inside the sterilization chamber does not guarantee that the core of the sample has reached sterilization temperature. In liquids, there can be a significant thermal delay: steam may reach 121 °C while the liquid is still below 100 °C.

This lag can lead to false positives if the sterilization time is counted too early.

Measuring directly inside the product allows you to:

✅ Ensure the entire sample has been properly treated.
✅ Avoid microbiological risks.
✅ Validate and optimize cycles using the F₀ value.

PT-100 Probe Models Available from RAYPA

The flexible PT-100 probes offered by RAYPA are designed to ensure precise control of the sterilization process, especially when monitoring liquid loads. For optimal functionality and proper integration with the autoclave control system, these probes must be installed at the factory.

Flexible Probe for Classic Line Autoclaves

References: PT-2, PT-2-B, PT-2-AH and PT-2-B-AH

These probes are specifically designed to monitor the sterilization of liquid loads in autoclaves from RAYPA’s Classic line.

They are available in several versions, compatible with the AES, AE-DRY, AE-B, AHS-N, AHS-DRY, and AHS-B series, with probe lengths varying according to the specific autoclave model (60 mm for benchtop models, 120 mm for vertical models).

Main Benefits:

Effective sterilization of liquids: The probe accurately measures temperature at the center of the liquid sample, ensuring that the required temperature is reached within the load. This significantly improves the reliability of the sterilization process.
Prevention of boilover effects: Continuous monitoring of liquid temperature minimizes the risk of overheating and spills when opening the autoclave. This protects both the operator and other contents of the autoclave chamber.
Optimization of sterilization processes: By simultaneously controlling the temperature in the chamber and inside the liquid, it provides more precise tracking of the F₀ value and cycle lethality. This facilitates more efficient sterilization, ensuring consistent results, regardless of the number or size of the processed containers.

Flexible Probe for Top Line Autoclaves

Reference: PT-2-TLV

Specifically recommended for accurate monitoring of liquid sterilization processes in RAYPA’s Top line autoclaves.

Compatible with RAYPA’s TLV-DUAL, TLV-PD, TLV-FA, and TLV-S autoclave models, all intended for critical applications requiring rigorous control. These units allow installation of up to two probes, enhancing versatility for monitoring. Some series, such as TLV-DUAL and TLV-FA, include one flexible probe as standard equipment.

Unlike the Classic line probes, the probe length varies depending on autoclave capacity and the specific needs of each sterilization process. This provides greater versatility, facilitating placement in various types of containers or different positions within the chamber.

Modes of use:

Single flexible probe: Allows direct monitoring of the internal temperature of the liquid sample, initiating the sterilization phase only once the desired temperature is reached. Additionally, installation of this probe enables programming cycles based on the F₀ value, optimizing lethality control and offering greater process flexibility.
Two flexible probes: Ideal for comparing conditions between different samples, especially when containers of varying sizes or positions within the chamber are used (such as upper and lower levels). The sterilization cycle starts only when both probes detect the required temperature, ensuring uniform treatment throughout the entire load.

Practical Recommendations for End Users

Choosing the right accessory to monitor temperature in an autoclave depends on the autoclave model, type of load, regulatory requirements, and process objectives.

👉 For liquids and culture media, a flexible PT-100 probe is always recommended.
👉 For heterogeneous loads, using two probes (in Top line models) helps identify cold spots and validate process uniformity.
👉 In laboratories subject to regulations such as GMP, FDA, or ISO 13485, it is essential to work with systems that enable F₀-based control, traceability, and report generation.

Common Errors When Using Probes in Autoclaves

Even with the appropriate probes, improper use can compromise the effectiveness of the sterilization process. Avoid the following mistakes:

🚫 Placing the probe in contact with the container wall (this distorts the measurement).
🚫 Using probes with damaged or uncalibrated cables.
🚫 Starting the cycle without confirming correct placement inside the sample.
🚫 Failing to verify probe compatibility with the autoclave model.

Expert tip

Always consult with the manufacturer or RAYPA’s technical support team to ensure you select accessories that are compatible with your specific model and application needs.

Do you have questions about which probe is best suited to your application? Our team of professionals is available to guide you and help you achieve safe, validated, and efficient sterilization.

19/03/202512/03/2025 by Aleix Nin

In the field of sterilization, choosing the right autoclave is essential to ensure efficiency and safety in the process.

Two of the most common options are vertical autoclaves and benchtop horizontal autoclaves, each with specific features that make them ideal for different applications.

In this article, we will explore their differences, advantages, and recommended uses in detail.

What Is the Difference Between a Vertical and a Horizontal Autoclave?

The main difference between a vertical autoclave and a horizontal autoclave lies in the loading orientation and the sterilization chamber design:

Vertical autoclaves: The load is inserted from the top. They are known for their large capacity, allowing for the sterilization of higher volumes of material in a single cycle.
Benchtop horizontal autoclaves: The load is placed from the front through a swing door. These autoclaves are compact and designed for space-constrained environments, making them ideal for smaller laboratories and clinical settings.

Dimensions and Space Requirements

Vertical autoclaves require more vertical space but optimize floor usage in laboratories and workspaces. In contrast, benchtop autoclaves are more compact, take up less height, and can be placed on tables or lab benches, making them ideal for small work areas.

Capacity and Recommended Uses

Vertical autoclaves: Designed for high-volume sterilization, they allow large quantities of materials to be processed in a single cycle. They are commonly used in laboratories, hospitals, and research facilities where efficiency is essential.
Benchtop autoclaves: Built for smaller loads and fast sterilization cycles, they are widely used in clinics, medical offices, and small labs where a compact solution is needed.

Pros and Cons of Vertical Autoclaves

Advantages of Vertical Autoclaves:

👍 Larger capacity: Ideal for sterilizing instruments, culture media, and bulky lab materials efficiently.

👍 Space optimization: While taller, they take up less floor space, maximizing lab layout efficiency.

👍 Versatile sterilization: Suitable for various materials, including liquids and large equipment.

Disadvantages of Vertical Autoclaves:

👎 Less ergonomic loading: Top-loading requires lifting materials, which can be challenging for heavy loads. However, lifting aids like fixed or mobile hoists improve safety and ease of use.
👎 Longer handling time: Loading and unloading may take longer compared to benchtop models, depending on the material type.

Pros and Cons of Benchtop Horizontal Autoclaves

Advantages of Benchtop Autoclaves:

✅ Compact design: Ideal for space-constrained environments, as they can be placed on tables, workbenches, or lab counters.
✅ Ergonomic loading: The front-loading system allows materials to be placed individually on the tray or directly inside the autoclave, reducing the need to lift heavy loads. Additionally, a transport trolley can be used to bring the load closer to the autoclave opening for easier and safer handling.
✅ Fast sterilization cycles: Designed for efficient processing of moderate volumes, making them ideal for clinics and small laboratories.

Disadvantages of Benchtop Autoclaves:

❌ Limited capacity: The cylindrical chamber design restricts space utilization, preventing full use of the corners and limiting the height of certain containers placed at the sides of the trays.
❌ Less versatile: Less efficient for large or bulky equipment or high volumes of liquid sterilization compared to vertical autoclaves.

How to Choose the Right Autoclave

Choosing between a vertical autoclave and a benchtop horizontal autoclave depends on several key factors:

Load volume: If you need to sterilize large quantities of material in a single cycle, a vertical autoclave is the best option.
Available space: For environments with limited space, a benchtop autoclave may be the most suitable alternative.
Application type: Laboratories handling bulky materials or large volumes of liquids will benefit from the higher efficiency of vertical autoclaves.

Autoclave Vertical vs Horizontal: Which One Should You Choose?

When comparing an autoclave vertical vs horizontal, the decision ultimately depends on your sterilization needs. If you prioritize capacity and efficiency, a vertical autoclave is the better choice. However, if you require a compact, front-loading system, a benchtop horizontal autoclave will be more practical.

In a nutshell

Both types of autoclaves provide effective sterilization solutions, but the right choice depends on your specific needs.

If you require a high-capacity solution for large sterilization loads, a vertical autoclave is the ideal option.

On the other hand, if you need a compact and efficient unit for moderate loads, a benchtop horizontal autoclave is the best alternative.

Still unsure which autoclave to choose? At RAYPA, we help you find the best sterilization solution for your laboratory. Contact us today for expert advice.

Sectors

Types of autoclaves